Where we are
Via Pietro Castellino 111
80131 Naples
Tel. 0039 081 6132 579
Links
Amministrazione trasparente
Seetharaman Parashuraman
Current Position:
Researcher
Contacts:
Group leader of the Cell Physiology Lab
Coordinator of the Euro-bioimaging Facility
Phone: +39 0816132312
Lab: +39 0816132312
Facility: +39 08161325643
Email: seetharaman.parashuraman@cnr.it
Keywords:
Secretory pathway, Golgi, TEM, Glycosilation, morphologyMy interests are in the following directions:
- How do morphological and structural features of cellular organelles contribute to their functions in physiological and pathological conditions?
- How did these structures evolve?
- Can we build cellular organelles (existing or alternate ones) based on our understanding of the system?
We address these questions by studying the eukaryotic secretory pathway especially the Golgi apparatus. An important part of the techniques we use is based on imaging and so we are also involved in developing imaging methods to facilitate our research.
Education
1999-2004 Ph.D., in life sciences from National Institute of Immunology (Jawaharlal Nehru University), New Delhi, India.
1997-1999 M.Sc., in Biotechnology from Pondicherry University, Pondicherry, India.
1994-1997 B.Sc., in Zoology with special emphasis on Biotechnology from Loyola College, Chennai, India.
Positions
2021- Group Leader, Institute of Experimental Endocrinology and Oncology, CNR, Naples, Italy
2020- Coordinator, Italian Advanced Light microscopy node of EuroBioimaging network.
2019-2021 Group Leader, Institute of Protein Biochemistry/Institute of Biochemistry and Cell Biology, CNR, Naples, Italy
2014-2019 Senior Researcher, Institute of Protein Biochemistry, CNR, Naples, Italy
2014- Head, Microscopy facility, CNR Castellino campus, Naples, Italy.
2012-2014 Researcher, Institute of Protein Biochemistry, CNR, Naples, Italy.
2009-2012 Post-doctoral fellow, Telethon Institute of Genetics and Medicine, Naples, Italy.
2005-2009 Post-doctoral fellow, Mario Negrisud Institute, S.Maria Imbaro, Italy.
Honours/Awards
Christian Boulin Fellowship (EMBL, Germany), International Travel grant (CSIR, India), Senior Research Fellowship (CSIR, India), Junior Research Fellowship (CSIR, India), Biotechnology fellowship (DBT, Govt of India), Gold medalist in B.Sc.,(Loyola College, India), Merit Scholarship (Loyola College, India), School topper in Chemistry (St.John’s SS School,India).
Patents
1. 2015 Kinase and ubiquitin ligase inhibitors and uses thereof. (No. 102015000084815)
1: Russo F,Sahu P,Agliarulo I,Rizzo R,Normanno N,Soddu S,Carlomagno F,Luini A,Parashuraman S. Prioritization of driver genes in cancer-associated copy number alterations identifies B4GALT5 as a glycooncogene. 2022 BioRXIV
2: Agliarulo I#, Parashuraman S#. Golgi Apparatus Regulates Plasma Membrane Composition and Function. Cells. 2022;11(3):368.
3: Pothukuchi P, Agliarulo I, Pirozzi M, Rizzo R, Russo D, Turacchio G, Nüchel J, Yang JS, Gehin C, Capolupo L, Hernandez-Corbacho MJ, Biswas A, Vanacore G, Dathan N, Nitta T, Henklein P, Thattai M, Inokuchi JI, Hsu VW, Plomann M, Obeid LM, Hannun YA, Luini A, D'Angelo G, Parashuraman S#. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. EMBO J. 2021,40(20):e107766.
4: Pothukuchi P, Agliarulo I, Russo D, Rizzo R, Russo F, Parashuraman S#. Translation of genome to glycome: role of the Golgi apparatus. FEBS Lett. 2019;593(17):2390-2411.
5: Hegde RN*, Parashuraman S*#, Iorio F, Ciciriello F, Capuani F, Carissimo A, Carrella D, Belcastro V, Subramanian A, Bounti L, Persico M, Carlile G, Galietta L, Thomas DY, Di Bernardo D, Luini A#. Unravelling druggable signalling networks that control F508del-CFTR proteostasis. Elife. 2015;4:e10365.
Non-academic publications:
1. D’angelo G and Parashuraman S (2012) The descent of language: A conversation between two jobless biologists S&F n. 10_2013; ISSN 2036-2927.
Researchers:
Marinella Pirozzi
m.pirozzi@ieos.cnr.it
Ilenia Agliarulo
I.agliarulo@ieos.cnr.it
PhD student:
Antonietta Esposito – a.esposito@ieos.cnr.it
Alumni:
Prathyush Pothukuchi
Annamaria Rondine
Giovanna Vanacore
Regione Campania (€ 10.5M), MIUR, Government of Italy (€ 16.6M), Dompe pharma (€ 324,000), Cystic Fibrosis Research Foundation, Italy (€ 80,000), National Research Council of Italy (€ 100,000)