Nina Dathan

Current Position:

Senior Technologist

Contacts:

Phone: +39 0816132494
Lab: +39 08161325495
Email: nina.dathan@cnr.it
n.dathan@ieos.cnr.it

Keywords:

Cloning, mutagenesis, glycosylation, cell trafficking

My scientific experience encompasses a wide range of molecular, cellular, physiological, and biochemical techniques contributing to an equally vast range of projects. Since being in Naples I’ve concentrated on the optimization of expression and purification of a wide range of recombinant proteins in E. coli, mainly of biomedical interest, as well as their biochemical and structural characterization. At IEOS I contribute at a supportive level to various research projects where cloning, mutagenesis, recombinant expression and protein purification are required in the study of regulatory mechanisms and membrane transport in eukaryotic cells, which when they become defective lead to cancer and other diseases

Education

1983: BSc. Applied Biology, Hertford University, GB
1992: Equivalent Degree Biological Sciences, University of Naples, Federico II

Positions

2021-present: Senior Technologist, IEOS, Naples
2010-present: Senior Technologist, Naples
2014-2018:     Guest, Imperial College, London, UK
2013-2021:     Technologist, Institute of Protein Biochemistry (IBP), Naples
2002-2007:     Scientific coordinator of the Recombinant Protein Group, BioGeM S.c.a.r.l., Naples
2001-2013:     Technologist, Institute of Biostructures and Bioimaging (IBB), Naples
1999:               Guest, NIH, Bethesda, USA
1997-2000:     Guest, Zoological Station “Anton Dohrn”, Naples
1997-2001:     Technologist, Biocrystallography Research Centre, Naples
1992-1996:     Cellular and Molecular Biology and Pathology dept., University of Naples, Federico II
1986-1991:     Research Assistant, EMBL, Heidelberg, Germany
1984-1985:     Jaques Monod Institute, Paris, France
1983-1984:     Technician, MRC, Cambridge, UK

Pothukuchi P, Agliarulo I, Pirozzi M, Rizzo R, Russo D, Turacchio G, Nüchel J, Yang JS, Gehin C, Capolupo L, Hernandez-Corbacho MJ, Biswas A, Vanacore G, Dathan N, Nitta T, Henklein P, Thattai M, Inokuchi JI, Hsu VW, Plomann M, Obeid LM, Hannun YA, Luini A, D'Angelo G, Parashuraman S. GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. EMBO J. (2021) 40(20)

Langella E, Buonanno M, Vullo D, Dathan N, Leone M, Supuran CT, De Simone G, Monti SM. Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of Carbonic Anhydrase IX. Cell Mol Life Sci. (2018) 75(17):3283-3296.

Capasso S, Sticco L, Rizzo R, Pirozzi M, Russo D, Dathan NA, Campelo F, van Galen J, Hölttä-Vuori M, Turacchio G, Hausser A, Malhotra V, Riezman I, Riezman H, Ikonen E, Luberto C, Parashuraman S, Luini A, D'Angelo G. Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network. EMBO J. (2017) 36(12):1736-1754.

Bellelli R, Castellone MD, Guida T, Limongello R, Dathan NA, Merolla F, Cirafici AM, Affuso A, Masai H, Costanzo V, Grieco D, Fusco A, Santoro M, Carlomagno F. NCOA4 transcriptional coactivator inhibits activation of DNA replication origins. Mol Cell. (2014) 55:123-37.

Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM. Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze". J.Enzyme Inhib Med Chem. (2014) 29(4):500-4.

Nina Dathan

Current Position:

Contacts:

Keywords:

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