A theragenerative bionanomaterial for bone cancer therapy and regeneration - Maria Grazia Raucci, IPCB-CNR
For several decades, cancer has been studied as a dangerto human life. Despite its shortcomings—side effects, limited effectiveness, poor targeting, and so on—conventional medicines have been widely used due to a lack of viable alternatives.The introduction of nanotechnology into medicine has opened new possibilities and given effective cancer treatment alternatives. Because of their large surface area, photoresponsivity, and electrical conductivity, 2D nanomaterials have lately received a lot of interest in nanomedicine.Black phosphorus (BP) is a 2D nanomaterial consists of multiple layers weakly bonded together through van der Waals forces; unique structure of BP makes it an appropriate drug/gene carrier, PTT/PDT, and imaging agent. One of the outstanding aspects of BP in comparison to other 2D materials is its selective anticancer action without the assistance of NIR or any other drugs, making BP stand out among a wide range of nanomaterials.BP nanosheet is also defined as theragenerativebionanomaterial for its multifunctionalnatureto induce therapy followed by repairing/regenerating the tissue/organ.The lectureaims to provide an overview of the design and development of BP-based nanosheets and nanocomposites and the therapeutic and regenerative effects on cancer and healthy cells.In particular, the antitumor effect of bare BP nanomaterials and nanocomposites was evaluated in vitroon bone, breast and prostate carcinoma cells;meanwhile, the regenerative behaviors of the nanocomposites were tested by in vitromodels with healthy osteoblasts and human mesenchymal stem cells.
Host: Domenico Russo (domenico.russo@cnr.it)
Conference Room, CNR, P. Castellino Campus
