Where we are
Via Pietro Castellino 111
80131 Naples
Tel. 0039 081 6132 579
Links
Amministrazione trasparente
Marcello Monti
Current Position:
Technologist, TI
Contacts:
Cell Regulation LAB
phone:
email: marcello.monti@ieos.cnr.it
marcello.monti@cnr.it
Keywords:
Shp1 phosphatase, breast cancer, melanoma, tumor microenvironment, cancer-related intracellular signaling, oncogenic pathwaysMy professional experiences have led me to acquire many scientific skills related to molecular and cellular biology, as well as biochemical techniques. My research activity focuses on the protein Shp1, an intracellular phosphatase that plays a key role in regulating inflammatory processes and cancer-related mechanisms, including tumor microenvironment, cell proliferation and metastasis.
The focus of our work is to characterize the role of Shp1 phosphatase in tumor invasion and modulation of the tumor microenvironment across different cancer models. Specifically, we investigate its involvement in breast cancer invasiveness and melanoma microenvironment dynamics.
The goal is to investigate the role of Shp1 phosphatase in cancer biology, with the aim of identifying potential therapeutic targets and developing targeted treatments for oncology.
Education:
February 2018 - PhD in Advanced Biomedical and Surgical Therapies - XXX cycle - at the University of Naples “Federico II”
June 2012 - Master’s degree in Medical Biotechnologies (cum laude) at the University of Naples “Federico II”
October 2009 - Bachelor’s degree in Health Biotechnologies at the University of Naples “Federico II”
Positions:
March 2025 to present: permanent position as Technologist at the National Research Council (CNR) Institute of Endotypes in Oncology, Metabolism and Immunology "G. Salvatore" (IEOMI), 2nd Unit (Naples)
July 2020-February 2025: research grants at the National Research Council (CNR) Institute of Experimental Endocrinology and Oncology “Gaetano Salvatore” IEOS, 2nd Unit (Naples)
January 2019-June 2020: Post-doc fellow (co-co-co contracts) at the Telethon Institute of Genetic and Medicine (TIGEM) (Pozzuoli, Naples)
November 2014-October 2017: PhD student (Advanced Biomedical and Surgical Therapies - XXX cycle) at the University of Naples “Federico II”
September 2012-December 2014: co-co-co contracts with the Advanced Biomedical Sciences Department of the University of Naples “Federico II”
Patents
Constructs comprising inteins (PCT/EP2021/059841). Auricchio A, Lyubenova H, Piccolo P, Monti M, Padula A, Esposito F.
- Tartaglione L, Loeffler CR, Miele V, Varriale F, Varra M, Monti M, Varone A, Bodi D, Spielmeyer A, Capellacci S, Penna A, Dell’Aversano C. Dereplication of Gambierdiscus balechii extract by LC-HRMS and in vitro assay: First description of a putative ciguatoxin and confirmation of 44-methylgambierone. Chemosphere (2023) doi: 10.1016/j.chemosphere.2023.137940
- Varone A, Amoruso C, Monti M, Patheja M, Greco A, Auletta L, Zannetti A, Corda D. The phosphatase
- Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function. Cell Commun Signal (2021) doi: 10.1186/s12964-021-00747-6
- Piccolo P, Padula A, Petruzzelli R, Philbert S, Church SJ, Campione S, Monti M, Capolongo F, Perna C, Nusco E, Schmidt HH, Cooper GJS, Polishchuk R. Full-length ATP7B reconstituted through protein trans-splicing corrects Wilson disease in mice. Mol Ther Methods Clin Dev (2022) doi: 10.1016/j.omtm.2022.08.004
- Monti M, Lupoli R, Sosa Fernandez LM, Cirillo F, Di Minno MND. Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies. Fertil Steril (2019) doi: 10.1016/j.fertnstert.2019.05.003
- De Rosa V*, Monti M*, Terlizzi C, Fonti R, Del Vecchio S, Iommelli F. Coordinate Modulation of Glycolytic Enzymes and OXPHOS by Imatinib in BCR-ABL Driven Chronic Myelogenous Leukemia Cells. Int J Mol Sci (2019) doi:10.3390/ijms20133134