Where we are
Via Pietro Castellino 111
80131 Naples
Tel. 0039 081 6132 579
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Amministrazione trasparente
Angela Filograna
My current research activity is focused on studying the regulation of intracellular metabolism and membrane trafficking. Using advanced microscopy, biochemical and cell biological techniques, I am now investigating the role played by ADP ribosylation during endocytosis depicting the cellular targets specifically controlled by this post-translational modification.
2016: PhD in Biomolecular Sciences, University of Studies of Campania “Luigi Vanvitelli”- Institute of Protein Biochemistry (IBP-CNR), Naples, Italy.
PhD project: Investigating Lipid Droplet biogenesis: role of CtBP1-S/BARS.
2013: Master’s Degree in Biology, University of Naples “Federico II”, Italy (final mark, 110/110 cum laude).
Title of thesis: Isolation and characterization of a Drosophila cln7 gene mutant, responsible late-infantile neuronal ceroid lipofuscinosis.
Positions
From Nov 2022 to present: Permanent position as Researcher at the Secondary Unit Institute of IEOS-CNR (Naples, Italy).
From June 2021 to Nov 2022: post-doc fellow at the Secondary Unit Institute of IEOS-CNR (Naples, Italy). Project “PHARMACOLOGICAL TARGETING OF CtBP1/BARS IN CANCER”.
From Jan 2020 to June 2021: post-doc fellow at the Institute of Biochemistry and Cell Biology (IBBC)-CNR (Naples, Italy). Project “Meccanismi molecolari nell’invasione tumorale e sviluppo di nuovi approcci terapeutici verso tumori resistenti agli attuali chemioterapici”.
From Jan 2017 to Dec 2019: post-doc fellow at the Institute of Protein Biochemistry (IBP)- CNR (Naples, Italy). Project “Il ruolo della proteina CtBP/BARS nella progressione tumorale: un bersaglio specifico per il trattamento farmacologico”.
2014-2016: doctoral fellow, CNR-Seconda Università degli Studi di Napoli (SUN), Naples, Italy.
2011-2013: pre-doctoral fellow, Institute of Genetics and Biophysics (IGB-CNR), Naples, Italy.
- Filograna, S. De Tito, M. Lo Monte, R. Oliva, F. Bruzzese, M.S. Roca, A. Zannetti, A. Greco, D. Spano, I. Ayala, A. Liberti, L. Petraccone, N. Dathan, G. Catara, L. Schembri, A. Colanzi, A. Budillon, A. R. Beccari, P. Del Vecchio, A. Luini, D. Corda, C. Valente. Identification and characterization of a new potent inhibitor targeting CtBP1/BARS in melanoma cells. J Exp Clin Cancer Res. (under revision). https://doi.org/10.21203/rs.3.rs-2921121/v1.
- Grimaldi G., Filograna A., Schembri L., Lo Monte M., Di Martino R., Pirozzi M., Spano D., Beccari A.R., Parashuraman S., Luini A., Valente C., Corda D. PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane. PNAS (2022). doi: 10.1073/pnas.2026494119
- Ferrara MA, Filograna A, Ranjan R, Corda D, Valente C, Sirleto L. Three-dimensional label-free imaging throughout adipocyte differentiation by stimulated Raman microscopy (2019). PLoS ONE. 14(5),e0216811.
- Guida V, Cernilogar FM, Filograna A, De Gregorio R, Ishizu H, Siomi MC, Schotta G, Bellenchi GC, Andrenacci D. Production of Small Noncoding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster (2016). 2016; 204:631-644.
- Pagliuso A, Valente C, Giordano LL, Filograna A, Li G, Circolo D, Turacchio G, Marzullo VM, Mandrich L, Zhukovsky MA, Formiggini F, Polishchuk RS, Corda D, Luini A. Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ (2016). Nature Comm. 7,12148.