Pranoy Sahu

Pranoy Sahu
Current Position:

Researcher, TD

Contacts:

Morpho-functional organization and regulation of the biosynthetic pathway lab


Phone: +39 0816132339
Lab: +39 0816132567
Email: p.sahu@ieos.cnr.it

Keywords:
Cell biology, Golgi complex, cancer

Glycosylation is a post-translational modification wherein sugars are sequentially added onto proteins and lipids and is fundamental to cell physiology and pathophysiology. The Golgi complex is a hub of different glycosylation biosynthetic enzymes i.e., glycotransferases and glycosidases, and machineries which includes, but not limited to, sugar nucleotide transporters, lipid transporters, peripheral Golgi proteins and GTPases, which coordinate and regulate the entire glycome of a cell.

My research mainly focuses on the following aspects:

  1. Studying the Golgi glycosylation machineries and their dynamics in the regulation of glycosylation.
  2. Identification of novel Golgi associated glyco-oncogenes and studying the onco-glycan MOA.
  3. Identification of predictive biomarkers based on onco-glycans or glyco-oncogene(s) to improve patient stratification and develop novel anticancer therapy.

To approach these goals, I apply basic cell and molecular biology techniques augmented with high-resolution microscopy techniques, mass-spectrometry, bioinformatics, and in vitro pharmacology.

Education:

Doctor of Philosophy (PhD) in Molecular life sciences
University of Campania Luigi Vanvitelli, Naples, Italy Nov’2017-Dec’2020
Master of Science in Medical Biotechnology
School of Life Sciences, Manipal, India Sept’2013 – Aug’2015
Gradation: First class EQF level 6

Positions:

Post-doctoral Researcher (Nov’2020-Oct’2023)
Istituto per l'endocrinologia e l'oncologia "Gaetano Salvatore" (IEOS), CNR, Napoli – Italy
Research Assistant (Aug’2016-May’2017)
School of Life Sciences, Manipal University- India
Research and Development Assistant (Sept’2015-Jul’2016)
Jawaharlal Nehru Centre for Advanced Scientific Research-India

  1. Sahu, P., Balakrishnan, A., Di Martino, R., Luini, A., & Russo, D. (2022). Role of the Mosaic Cisternal Maturation Machinery in Glycan Synthesis and Oncogenesis. Frontiers in cell and developmental biology, 10.
  2. Russo, F*., Sahu, P*., Agliarulo, I., Rizzo, R., Monte, M. L., Luini, A., Parashuraman, S. (2022). Prioritization of driver genes in cancer-associated copy number alterations identifies B4GALT5 as a glycooncogene. bioRxiv. [* co-first author].
  3. Rizzo, R., Russo, D., Kurokawa, K., Sahu, P., Lombardi, B., Supino, D., Zhukovsky, M.A., Vocat, A., Pothukuchi, P., Kunnathully, V. and Capolupo, L., 2021. Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3. The EMBO Journal, p.e107238.
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Where we are

Via Pietro Castellino 111
80131 Naples
Tel. 0039 081 6132 579

Links

Amministrazione trasparente

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