Where we are
Via Pietro Castellino 111
80131 Naples
Tel. 0039 081 6132 579
Links
Amministrazione trasparente
Maria Matarese
Current Position:
Technologist
Contacts:
Contacts: +39 0816132495 Lab
Phone: +39 0816132631
Email: m.matarese@ieos.cnr.it
Keywords:
cell signaling, cancer, viral infection, MARylation, PARPs, intracellular transportMy research experience includes a wide range of molecular, cellular and biochemical techniques. Currently, I am involved in two main research activities, namely i)study of signaling pathways in membrane trafficking and in cancer biology and ii) study of the host-virus interactions occurring during infection. Using advanced biochemical and cell biological techniques, I am specifically focusing on the role played by mono-ADP-ribosylation (MARylation) in cancer cells, through the identification of specific targets controlled by this post-translational modification.
On the other hand, I am involved in research studies related to the role of MARylation in viral infection. Indeed, the role played by MARylation during viral entry and in the identification of cellular and viral targets controlled by this post-translational modification is an important focus for finding ways to limit viral infection and/or reduce disease severity associated with the virus.
In parallel, my expertise has revealed to be useful in administrative activities of the laboratory and therefore I hold the role of lab manager.
Education
October 2012: Master Degree in Biological Sciences, University of Naples “Federico II”, Italy; Thesis Summa cum Laude. Project: "In the presence of paclitaxel mir-34c has an unexpected antiapoptotic role in NSCLC cells” at CNR-IEOS Institute,
October 2010: Bachelor Degree in Biological Sciences, University of Naples “Federico II”, Italy; Thesis: “Analisi di due geni associati al locus mrx81 in una famiglia affetta da ritardo mentale x-linked” at CNR-IGB Institute
Positions
March 2024 to present: Permanent position as Technologist at the National Research Council (CNR, Naples) at the Institute of Experimental Endocrinology and Oncology “Gaetano Salvatore” 2nd Unit (Naples);
May 2021 to Feb 2024: fellow at the CNR Institute of Experimental Endocrinology and Oncology “Gaetano Salvatore” 2nd Unit (Naples);
Gen 2017-Apr2021: co-co-co contract at the Telethon Institute of Genetic and Medicine (TIGEM) (Pozzuoli, Naples);
Gen 2015 - Dec 2016: Fellowship at Telethon Institute of Genetic and Medicine (TIGEM) (Pozzuoli, Naples);
Jun 2014- Aug 2014: pre-Doctoral Fellowship at Neuromed; the research activities have been performed at CNR-IGB Institute (Naples);
Aprl 2013- Mar 2014: Fellowship P.O.R. Campania FSE 2007-2013, Progetto CRÈME at the University of Naples Federico II, Department of Biology.
1. PARP10 mediates mono-ADP-ribosylation of Aurora-A regulating G2/M transition of the cell cycle S Di Paola, M Matarese, ML Barretta, N Dathan, A Colanzi, D Corda, G Grimaldi; Cancers 2022 Oct 24; DOI: 10.3390/cancers14215210
2. c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder P S Contreras, P J Tapia, L González-Hódar, I Peluso, C Soldati, G Napolitano, M Matarese, MLas Heras, Cristian Valls, A Martinez, E Balboa, J Castro, N Leal, F M Platt, A Sobota, D Winter, A D Klein, D L Medina, A Ballabio, A R Alvare, S Zanlung; iScience 2020 Oct 15;23(11):101691. doi: 10.1016/j.isci.2020.101691.
3. A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome G Napolitano, C Di Malta, A Esposito, M E G de Araujo, Salvatore Pece, G Bertalot, M Matarese, V Benedetti, A Zampelli, T Stasyk, D Siciliano, A Venuta, M Cesana, C Vilardo, E Nusco, J Monfregola, A Calcagnì, P Paolo Di Fiore, L A Huber, A Ballabio; Nature 2020 Jul 1.; doi: 10.1038/s41586-020-2444-0.
4. mTOR- dependent phosphorylation controls TFEB nuclear export G Napolitano, A Esposito, H Choi, V Benedetti, M Matarese, C Di Malta, J Monfregola, D L Medina, J Lippincott Schwartz and A Ballabio; Nature Communication 2018 Aug 17;9(1):3312. doi: 10.1038/s41467-018-05862-6.
5. MDM2-mediated degradation of p14ARF: a novel mechanism to control ARF levels in cancer cells M Vivo, M Matarese, M Sepe, R Di Martino, LFesta, V Calabrò, G La Mantia, A Pollice; PLoS; One. 2015; 10(2): e0117252. DOI 10.1371/journal.pone.0117252