Cell Biology and Drug Discovery
Keywords: Cell biology, Imaging, Cancer, Lipid droplets, Membrane trafficking, Viral infection, Drugs
Group leader: Carmen Valente
Contacts:
Phone: +39 0816132 579|225
Lab: +39 08161325225
Email: carmen.valente@cnr.it
c.valente@ieos.cnr.it
- Research Focus
- Key Publications
- Research Group
- Projects and Grants
- News & Press Releases
- Projects and Grants
The research activity of our group is to define the molecular mechanisms that underline the intracellular carrier formation required to support membrane traffic in physiology and pathology and to use this knowledge to identify new pharmacological targets.
We have characterized a novel fission machinery that controls several exocytic and endocytic transport routes. We have defined how this protein complex machinery is assembled and regulated and how it cooperates with local membrane lipids during the formation of the basolaterally directed post-Golgi carriers.
Based on these knowledges and expertise, using advanced microscopy, biochemical and cell biological techniques our group is focused on:
- membrane transport alteration in cancer (endo/ exocytosis) and viral infection;
- membrane transport alteration in lipodystrophy;
- lipid droplet regulation and cellular functions in physiology and pathology;
- developing pseudovirus based host cell infection/internalization cell imaging assays to study viral infection.
Three-dimensional label-free imaging throughout adipocyte differentiation by stimulated Raman microscopy.
PLoS ONE. 14(5): e0216811 (2019)
M.A. Ferrara, A. Filograna, R. Ranjan, D. Corda, C. *Valente, L. Sirleto.
A reliable Raman-spectroscopy-based approach for diagnosis, classification and follow-up of B-cell acute lymphoblastic leukemia.
Nature Sci. Rep. 6 24821 (2016)
S. Managò, C. *Valente, P. Mirabelli, D. Circolo, F. Basile, D. Corda, A. C. De Luca
Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ.
Nat Communs 7:12148 (2016)
A. Pagliuso, C. *Valente, LL. Giordano, A. Filograna, G. Li, D. Circolo, G. Turacchio, VM. Marzullo, L. Mandrich, MA. Zhukovsky, F. Formiggini, RS. Polishchuk, D. Corda, A. Luini.
A 14-3-3g dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation.
Nat. Cell Biol. 4:343-354 (2012)
C.*Valente, G. Turacchio, S. Mariggiò, A. Pagliuso, R. Gaibisso, G. Di Tullio, M. Santoro, F. Formiggini, S. Spanò, D. Piccini, RS. Polishchuk, A. Colanzi, A. Luini, D. Corda.
Rab6 and myosin II at the cutting edge of membrane fission
Nat. Cell Biol. 7: 635-638 (2010)
C.*Valente, R. Polishchuk, MA. De Matteis.
Researcher:
Angela Filograna a.filograna@ieos.cnr.it
PhD student:
Miriam Lucariello m.lucariello@ieos.cnr.it
Staff Technician:
Gabriele Turacchio g.turacchio@ieos.cnr.it
Pre-doctoral fellow (shared with IPCB-CNR):
Ashkan Bigham ashkan.bigham@ipcb.cnr.it
Graduate student:
Valeria Conte valeria.conte1@studenti.unicampania.it
2019-2024. Coordinator of the OR/ PON Potenziamento Infrastruttura Europea Progetto IMPARA - Imaging dalle molecole alla preclinica- PIR01_00023
2020-2021. Co-Principal Investigator: “RECOVER-COVID19” (RicErCa e sviluppOVERsus COVID19 in Campania) financed by Campania Region.
2018-2021. Principal Investigator: “Analysis of bio-distribution and metabolism of new chemical compounds in animal model of several cancer tissues and in muscle tissue by Imaging-Mass-Spectrometry (IMS) technology”, granted by Dompé farmaceutici S.p.A.
2016-2018. Principal Investigator: “Role of Acylglycerol-3-Phosphate Acyltransferases in membrane transport alterations in cancer”, TRansforming IDEas in Oncological (TRIDEO) Research Funding supported by Italian Association for Cancer Rerearch and Cariplo Fondation.
2015-2016. Principal Investigator: “Analyzing the role of CtBP1/BARS in neuronal membrane trafficking and polarization” supported by Program of Bilateral Collaboration Italy-Argentine CNR/CONICET
- Mamma e ricercatrice CNR Carmen Valente scende in campo con Lega calcio Serie B a sostegno della ricerca CNR sul COVID19
- Facebook https://www.facebook.com/UfficioStampaCnr/videos/635956903634823
- Instragram https://www.instagram.com/tv/B-hxnXwhev8/?utm_source=ig_web_copy_link
- Twitter https://twitter.com/StampaCnr/status/124612517518093926
- Riconoscimenti per Pubblicazioni:
- Pagliuso A, Valente C, Giordano LL, Filograna A, Li G, Circolo D, Turacchio G, Marzullo VM, Mandrich L, Zhukovsky MA, Formiggini F, Polishchuk RS, Corda D, Luini A. Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ. Nat Communs (2016) 7 :12148
https://f1000.com/prime/726500356 (07/12/2016)
- Valente C, Turacchio G, Mariggiò S, Pagliuso A, Gaibisso R, Di Tullio G, Santoro M, Formiggini F, Spanò S, Piccini D, Polishchuk RS, Colanzi A, Luini A, Corda D. A 14-3-3g dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation. Cell Biol. (2012) 4:343-354.
https://f1000.com/prime/14078956 (26/02/2012)
- “IL LABIRINTO DI CRISTALLO” la dimensione di genere nelle carriere scientifiche. UNA MOSTRA PER RACCONTARE LA DIMENSIONE DI GENERE NELLA SCIENZA
- Gli 11 giovani ricercatori premiati oggi per progetti di ricerca oncologica di frontiera: “TRansforming IDEas in Oncological Research” TRIDEO 2015
https://www.fondazionecariplo.it/static/upload/air/airc_scheda-ricercatori_trideo/airc_scheda-ricercatori_trideo.pdf
2019-2024. Coordinator of the OR/ PON Potenziamento Infrastruttura Europea Progetto IMPARA - Imaging dalle molecole alla preclinica- PIR01_00023
2020-2021. Co-Principal Investigator: “RECOVER-COVID19” (RicErCa e sviluppOVERsus COVID19 in Campania) financed by Campania Region.
2018-2021. Principal Investigator: “Analysis of bio-distribution and metabolism of new chemical compounds in animal model of several cancer tissues and in muscle tissue by Imaging-Mass-Spectrometry (IMS) technology”, granted by Dompé farmaceutici S.p.A.
2016-2018. Principal Investigator: “Role of Acylglycerol-3-Phosphate Acyltransferases in membrane transport alterations in cancer”, TRansforming IDEas in Oncological (TRIDEO) Research Funding supported by Italian Association for Cancer Rerearch and Cariplo Fondation.
2015-2016. Principal Investigator: “Analyzing the role of CtBP1/BARS in neuronal membrane trafficking and polarization” supported by Program of Bilateral Collaboration Italy-Argentine CNR/CONICET
