Where we are
Via Pietro Castellino 111
80131 Naples
Tel. 0039 081 6132 579
Links
Amministrazione trasparente
Pranoy Sahu
Current Position:
Researcher, TD
Contacts:
Morpho-functional organization and regulation of the biosynthetic pathway Lab
Phone: +39 0816132339
Lab: +39 0816132567
Email: p.sahu@ieos.cnr.it
Keywords:
Cell biology, BARS, pharmacology, traffickingThe research activity of the lab is to define the molecular mechanisms that underline the intracellular carrier formation required to support membrane traffic in physiology and pathology and use this knowledge to identify new pharmacological target.
We have characterized a novel fissioning machinery that controls several exocytic and endocytic transport routes. We have defined how this protein complex-machinery is assembled and regulated and how it cooperates with local membrane lipids during the formation of the basolaterally directed post-Golgi carriers.
Based on these knowledges and expertise, using advanced microscopy, biochemical and cell biological techniques the lab is focus on:
- membrane transport alteration in cancer (endo- and exo-cytosis) and viral infection;
- membrane transport alteration in lipodystrophy;
- lipid droplets regulation and cellular functions in physiology and pathology;
- developing of new cell imaging techniques.
Education
2011 PhD (with honour) in Ph.D. in Life Sciences, Open University, UK. Sponsoring establishments: “Mario Negri Sud" Institute and Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy
2003 Master degree in in Chemistry and Technological Pharmaceutics (cum laude), University of Chieti-Pescara “G. d’Annunzio”, Italy.
Positions
2021-present: Researcher and Responsible Secondary Unit Institute of Endocrinology and Experimental Oncology “G. Salvatore” – IEOS – National Research Council of Italy, Naples.
2019-2021: Researcher at IBBC – National Research Council of Italy, Naples.
2017-2011: Researcher at IBP – National Research Council of Italy, Naples.
2010-2011: Telethon Postdoctoral fellow at IBP – National Research Council of Italy, Naples.
2008-2009: Doctoral Fellow at the Department of Cell Biology and Oncology, “Mario Negri Sud” Research Institute, Santa Maria Imbaro, Chieti, Italy.
2005-2007: Italian Foundation for Cancer Research (FIRC, Italy) Fellow at the Department of Cell Biology and Oncology, “Mario Negri Sud” Research Institute, Santa Maria Imbaro, Chieti, Italy.
Honours/Awards
2022: Invitation from the President of the Senate of the Italian Republic to represent the female scientists of CNR - The future is woman? of the “Senate & Culture” series of events, March 2022, Rome, Italy.
2018: Scientific career recognition awarded by “Academy and Research in the living room of Consul General Mary Ellen Countryman”, May 2018, Naples, Italy.
2016: “Young Biologists Prize 2015-2016”, Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”, National Research Council, Naples, Italy.
2016-2011: Recognition for the publication of
1) Pagliuso A, Valente C et al., Nat Communs. (2016) 7:12148. *Classified by the Faculty of 1000 in the top 2% of papers published in 2016 in medicine and biology.
2) Valente C et al., Nat Cell Biol. (2012) 4:343-54. *Classified by: i) the Faculty of 1000 in the top 2% of papers published in 2012 in medicine and biology; ii) the Italian Association for Cancer Research (AIRC) as one of the top 10 papers published from projects financed by AIRC in 2012; iii) the Italian National Research Council as one of the published CNR highlights of 2011/2012.
3) Yang JS, Valente C et al., Nat Cell Biol. (2011) 8:996-1003. *Classified by the Italian National Research Council as one of the published CNR highlights of 2010/2011.
PKD-dependent PARP12-catalyzed mono-ADP ribosylation of Golgin-97 is required for E-cadherin transport from Golgi to plasma membrane.
Proc. Natl. Acad. Sci. USA. 119(1): e2026494119 (2022)
G. Grimaldi, A. Filograna, L. Schembri, M. Lo Monte, R. Di Martino, M. Pirozzi, D. Spano, AR. Beccari, S. Parashuraman, A. Luini, C.* Valente, D Corda.
Nature Sci. Rep. 6 24821 (2016)
S. Managò, C.* Valente, P. Mirabelli, D. Circolo, F. Basile, D. Corda, A. C. De Luca
Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ.
Nat Communs 7:12148 (2016)
A. Pagliuso, C.* Valente, LL. Giordano, A. Filograna, G. Li, D. Circolo, G. Turacchio, VM. Marzullo, L. Mandrich, MA. Zhukovsky, F. Formiggini, RS. Polishchuk, D. Corda, A. Luini.
A 14-3-3g dimer-based scaffold bridges CtBP1-S/BARS to PI(4)KIIIβ to regulate post-Golgi carrier formation.
Nat. Cell Biol. 4:343-354 (2012)
C.* Valente, G. Turacchio, S. Mariggiò, A. Pagliuso, R. Gaibisso, G. Di Tullio, M. Santoro, F. Formiggini, S. Spanò, D. Piccini, RS. Polishchuk, A. Colanzi, A. Luini, D. Corda.
Rab6 and myosin II at the cutting edge of membrane fission
Nat. Cell Biol. 7: 635-638 (2010)
C.* Valente, R. Polishchuk, MA. De Matteis.
Researcher:
Angela Filograna a.filograna@ieos.cnr.it
Fellow:
Ashkan Bigham (sharing with IPCB-CNR) ashkanbigham@gmail.com
PhD student:
Miriam Lucariello m.lucariello@ieos.cnr.it
Master Student:
Valeria Conte valeria.conte1@studenti.unicampania.it
2019-2024. Coordinator of the OR/ PON Potenziamento Infrastruttura Europea Progetto IMPARA - Imaging dalle molecole alla preclinica- PIR01_00023
2020-2021. Co-Principal Investigator: “RECOVER-COVID19” (RicErCa e sviluppOVERsus COVID19 in Campania) financed by Campania Region.
2018-2021. Principal Investigator: “Analysis of bio-distribution and metabolism of new chemical compounds in animal model of several cancer tissues and in muscle tissue by Imaging-Mass-Spectrometry (IMS) technology”, granted by Dompé farmaceutici S.p.A.
2016-2018. Principal Investigator: “Role of Acylglycerol-3-Phosphate Acyltransferases in membrane transport alterations in cancer”, TRansforming IDEas in Oncological (TRIDEO) Research Funding supported by Italian Association for Cancer Rerearch and Cariplo Fondation.
2015-2016. Principal Investigator: “Analyzing the role of CtBP1/BARS in neuronal membrane trafficking and polarization” supported by Program of Bilateral Collaboration Italy-Argentine CNR/CONICET.